Nicholas Christopher-Hayes

EDUCATION

2021 – PRSNT PhD, Psychology, University of California, Davis

Relevant Courses: Statistical Analysis in Psychological Research, Fundamentals of Cognitive Neuroimaging, Cognitive and Perceptual Development, Causal Modeling and Correlational Data, Cognitive Neuroscience, Advanced Statistical Inference from Psychological Experiments

Research Projects: Longitudinal Changes of Hippocampal Subfields Predict Memory Improvements at the Transition into Adolescence

2011 – 2015 BA, Psychology, University of Wisconsin, Milwaukee

Relevant Courses: Child Psychology, Psychological Statistics, Research Methods, Neuropsychology, Advanced Physiological Psychology, Cellular & Molecular Neuroscience, Brain Injury, Cognitive Neuroscience, Computer Science (Java 1), Computer Science (Java 2)

Senior Research Project: Oculomotor capture by aversive stimuli

PROFESSIONAL RESEARCH EXPERIENCE

MAD Lab:

2021 – PRSNT Doctoral Student, (Y3)

PI: Dr. Simona Ghetti

University of California Davis, Psychology

DICoN Lab:

2019 – 2021 MEG Research Associate

PI: Dr. Tony W. Wilson

Boys Town National Research Hospital, Institute for Human Neuroscience

University of Nebraska Medical Center, Department of Neurological Sciences

-Processing and analysis of Magnetic Resonance Imaging (MRI), Magnetoencephalography (MEG), Positron Emission Tomography (PET), Arterial Spin Labelling (ASL), and Electromyography (EMG) data

-Processing pipeline and toolbox development

-Computer and data management

-Lab wiki development and maintenance

-Research study and cognitive task development

-Manuscript and figure preparation for inclusion in scholarly conference presentations and publications

WN Lab:

2016 – 2019 Clinical Research Associate

PI: Dr. David E. Warren

University of Nebraska Medical Center, Department of Neurological Sciences

-Participant data collection with MRI, MEG, Transcranial Magnetic Stimulation (TMS), computerized tasks, and Eye-tracking

-Data processing and quality control

-Computer and data management

-Develop and implement research study protocols

-Manuscript and figure preparation for inclusion in scholarly conference presentations and publications

MINDfull of Memory Lab:

2013 – 2016 Research Assistant

PI: Dr. Deborah E. Hannula

University of Wisconsin-Milwaukee, Department of Psychology

-Participant data collection with computerized tasks and Eye-tracking hardware

-Behavioral and Eye-tracking data analysis

-Present and lead discussion in weekly lab meetings

OTHER PROFESSIONAL EXPERIENCE

La Fleur Law Office, S.C.:

2015 – 2016

Firm Administrator, Milwaukee, WI

2012 – 2015 Law Clerk, Milwaukee, WI

UWM Men’s Panther Soccer Club:

2015 – 2016

President, Milwaukee, WI

FUNDED AWARDS

Graduate Funding:

2022 – 2023 Investigating Hippocampal Contribution to Memory Development in Healthy Children and Children with Chronic Asthma, Learning-Memory-Plasticity (LaMP) Program, NIH T32 MH112507 ($54,000), Role: Doctoral Student Trainee

2022 Linking Chronic Asthma to Memory Impairments in Children, UC Davis Memory and Plasticity (MAP) Program ($25,000), PI: Simona Ghetti, Role: Doctoral Student Researcher

Undergraduate Funding:

2015 Support for Undergraduate Research Fellows (SURF) ($1,500), University of Wisconsin, Milwaukee

PUBLICATIONS

Published:

Christopher-Hayes, N.J., Embury, C. M., Wiesman, A.I., May, P.E., Schantell, M., Johnson, C.M., Wolfson, S.L., Murman, D.L., Wilson, T.W. (2023). Piecing it together: hippocampal subfield profiles relate to cognitive impairment along the Alzheimer’s disease spectrum. Frontiers in Aging Neuroscience, Section Alzheimer’s Disease and Related Dementias. Public Link

Picci, G., Casagrande, C.C., Ott, L.R., Petro, N.M., Christopher-Hayes, N.J., Johnson, H.J., Willett, M.P., Okelberry, H.J., Wang, Y.-P., Stephen, J.M., Calhoun, V.D., Wilson, T.W. (2023). DHEA mediates associations between trauma-related symptoms and anterior pituitary volume in children and adolescents. Human Brain Mapping. Public Link Coming Soon, DOI: 10.1002/hbm.26516.

Rempe, M.P., Wiesman, A.I., Murman, D.L., May, P.E., Christopher-Hayes, N.J., Wolfson, S.L., Johnson, C.M., Wilson, T.W. (2023). Sleep quality differentially modulates neural oscillations and proteinopathy in Alzheimer’s disease. eBioMedicine 92, 104610. Public Link

Picci, G., Christopher-Hayes, N.J., Petro, N.M., Taylor, B.K., Eastman, J.A., Frenzel, M.R., Wang, Y.-P., Stephen, J.M., Calhoun, V.D., Wilson, T.W. (2022). Amygdala and hippocampal subregions mediate outcomes following trauma during typical development: Evidence from high-resolution structural MRI. Neurobiology of Stress. Public Link

Rempe, M., Ott, L.R., Picci, G., Penhale, S.H., Christopher-Hayes, N.J., Schantell, M., Johnson, H.J., Okelberry, H.J., Losh, K.L., Willett, M.P., Losh, R.A., Wang, Y.-P., Stephen, J.M., Calhoun, V.D., Heinrichs-Graham, E., Kurz, M.K., Wilson, T.W. (2022). Spontaneous cortical dynamics from the first years to the golden years. PNAS 120, e2212776120. https://www.pnas.org/doi/10.1073/pnas.2212776120

Springer, S.D., Wiesman, A.I., May, P.E., Schantell, M., Johnson, H.J., Willet, M.P., Castelblanco, C.A., Eastman, J.A., Christopher‐Hayes, N. J., Wolfson, S.L., Johnson, C.M., Murman, D.L., Wilson, T.W. (2022). Altered visual entrainment in patients with Alzheimer’s disease: magnetoencephalography evidence. Brain Communications. Public Link

Rempe, M., Lew, B.J., Embury, C.M., Christopher-Hayes, N.J., Schantell, M., Wilson, T.W. (2022). Spontaneous sensorimotor beta power and cortical thickness uniquely predict. NeuroImage 263, 119651. Public Link

Christopher-Hayes, N.J., Lew, B.J., Wiesman, A.I., Schantell, M., O’Neill, J., May, P.E., Swindells, S., Wilson, T.W. (2021). Cannabis use impacts pre-stimulus neural activity in the visual cortices of people with HIV. Human Brain Mapping. Public Link

Wiesman, A.I., Christopher-Hayes, N.J., Wilson, T.W. (2021b). Stairway to memory: Left-hemispheric alpha dynamics index the progressive loading of items into a short-term store. NeuroImage 235, 118024. Public Link

Wiesman, A.I., Murman, D.L., Losh, R.A., Schantell, M., Christopher‐Hayes, N.J., Johnson, H.J., Willet, M.P., Wolfson, S.L., Losh, K.L., Johnson, C.M., May, P.E., Wilson, T.W. (2021). Spatially resolved neural slowing predicts impairment and amyloid burden in Alzheimer’s disease. BRAIN. Public Link

Warren, D.E., Rangel, A.J., Christopher‐Hayes, N.J., Eastman, J.A., Frenzel, M.R., Stephen, J.M., Calhoun, V.D., Wang, Y., Wilson, T.W. (2021). Resting‐state functional connectivity of the human hippocampus in periadolescent children: Associations with age and memory performance. Human Brain Mapping. Public Link

Wiesman, A.I., Murman, D.L., May, P.E., Schantell, M., Losh, R.A., Johnson, H.J., Willet, M.P., Eastman, J.A., Christopher‐Hayes, N.J., Knott, N.L., Houseman, L.L., Wolfson, S.L., Losh, K.L., Johnson, C.M., Wilson, T.W. (2021c). Spatio‐spectral relationships between pathological neural dynamics and cognitive impairment along the Alzheimer’s disease spectrum. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring 13. Public Link

Wiesman, A.I., Christopher-Hayes, N.J., Eastman, J.A., Heinrichs-Graham, E., Wilson, T.W. (2021). Response certainty during bimanual movements reduces gamma oscillations in primary motor cortex. NeuroImage 224, 117448. Public Link

Arif, Y., Wiesman, A.I., Christopher-Hayes, N.J., Wilson, T.W. (2021). Aberrant inhibitory processing in the somatosensory cortices of cannabis-users. Journal of Psychopharmacology. Public Link

In prep:

Christopher-Hayes, N.J., Haynes, S.C., Kenyon, N.J., Merchant, V.D., Schweitzer, J.B., Ghetti, S. Exploring Memory Functioning in Children with Asthma: Insight from the ABCD Study.

Christopher-Hayes, N.J., Johnson, E.G., Mooney, L.N., Kazemi, A., Lee, J.K., Fandakova, Y., Bunge, S.A., Ghetti, S. Longitudinal Changes of Hippocampal Subfields Predict Memory Improvements at the Transition into Adolescence.

INTER/NATIONAL CONFERENCES

Christopher-Hayes, N.J., Haynes, S.C., Kenyon, N.J., Merchant, V.D., Schweitzer, J.B., Ghetti, S. (2023). Exploring Memory Functioning in Children with Asthma: Insight from the ABCD Study. FLUX Society International Conference.

Picci, G., Petro, N.M., Casagrande, C.C., Ott, L.R., Christopher-Hayes, N.J., Johnson, H.J., Willet, M.P., Okelberry, H., Wang, Y.-P., Stephen, J.M., Calhoun, V.D., Wilson, T.W. (2023). Anterior pituitary volume mediates associations between pubertal hormones and changes in dysregulation symptoms in youth. FLUX Society International Conference.

Casagrande, C.C., Picci, G., Petro, N.M., Ott, L.R., Christopher-Hayes, N.J., Eastman, J.A., Frenzel, M.R., Wang, Y.-P., Stephen, J.M., Calhoun, V.D., Wilson, T.W. (2022). Salivary DHEA mediates associations between trauma-related anxiety symptoms and anterior pituitary volume in adolescents. Biological Psychiatry.

Picci, G., Christopher-Hayes, N.J., Petro, N.M., Taylor, B.K., Eastman, J.A., Frenzel, M.R., Wang, Y.-P., Stephen, J.M., Calhoun, V.D., Wilson, T.W. (2022). High-Resolution Structural MRI Suggests Protective Effects of Amygdala and Hippocampal Subregional Volume Following Traumatic Experiences‬. Biological Psychiatry.

Christopher-Hayes, N.J., Embury, C.M., Wiesman, A.I., May, P.E., Schantell, M., Johnson, C.M., Wolfson, S. L., Murman, D.L., Wilson, T.W. (2021). Piecing it together: relationships between hippocampal subfields and cognitive impairment along the Alzheimer’s disease spectrum. Alzheimer’s Association International Conference.

Christopher-Hayes, N.J., Embury, C.M., Wiesman, A.I., May, P.E., Schantell, M., Johnson, C.M., Wolfson, S.L., Murman, D.L., Wilson, T.W. (2021). Hippocampal subfield profiles relate to cognitive impairment along the Alzheimer’s disease spectrum. Organization for Human Brain Mapping.

Jing, R., Christopher-Hayes, N.J., Rangel, A.J., Murman, D.L., Warren, D.E. (2020). Effect of Targeted Transcranial Magnetic Stimulation on Memory Performance in Older Adults with Amnestic Mild Cognitive Impairment. Journal of the American Geriatrics Society.

Phipps, C.J., Rangel, A., Christopher-Hayes, N.J., Phatak, V., Murman, D.L., Warren, D.E. (2020). Measuring change in memory networks after targeted repetitive transcranial magnetic stimulation. Organization for Human Brain Mapping.

Phipps, C.J., Rangel, A., Christopher-Hayes, N.J., Phatak, V., Murman, D.L., Warren, D.E. (2019). Measuring brain and cognitive changes in memory systems after targeted multiday repetitive transcranial magnetic stimulation of healthy young, healthy old, and amnestic mild cognitive impairment(aMCI) participants. Alzheimer’s Association International Conference.

Ellis, D.G., White, M.L., Hayasaka, H., Christopher-Hayes, N.J., Warren, D.E., Wilson, T.W., Aizenberg, M.R. (2019). Accurate localization of primary motor cortex in brain tumor patients with DTI and deep learning. Radiological Society of North America.

Ellis, D.G., White, M.L., Hayasaka, H., Christopher-Hayes, N.J., Warren, D.E., Wilson, T.W., Aizenberg, M.R. (2019). Reliability of Functional Neuroimaging for Prediction of Eloquent Brain Function as Determined by Intraoperative Mapping in Brain Tumor Patients. Radiological Society of North America.

Datta, P., Samson, K.K., Warren, D.E., Christopher-Hayes, N.J., Malgireddy K.R. (2019). Assessment of clinical and imaging characteristics in medically refractory epilepsy with poor surgical outcomes. American Epilepsy Society.

Warren, D.E., Christopher-Hayes, N.J., Rangel, A., Stephen, J.M., Calhoun, V.D., Wang, Y.-P., Wilson, T.W. (2018). Measuring the relationship between memory performance and hippocampal structure/function in periadolescent children: a longitudinal investigation from the Dev-CoG project. Nanosymposium. Society for Neuroscience.

Christopher-Hayes, N.J., Rangel, A., Stephen, J.M., Calhoun, V.D., Wang, Y.-P., Wilson, T.W., & Warren, D.E. (2017). Adolescent changes in hippocampal volume and functional connectivity affect memory performance. Organization for Human Brain Mapping.

Spooner, R.K., Christopher-Hayes, N.J., Stephen, J.M., Calhoun, V.D., Wang, Y.-P., Wilson, T.W., & Warren, D.E. (2017). Intrinsic functional connectivity of the striatum covaries with cognitive performance in adolescents. Organization for Human Brain Mapping.

Spooner, R.K., Christopher-Hayes, N.J., Stephen, J.M., Calhoun, V.D., Wang, Y.-P., Wilson, T.W., & Warren, D.E. (2017). Childhood development of behavioral and brain network changes related to basal ganglia: resting-state functional connectivity of striatal regions varies with performance on cognitive tasks in children. Cognitive Neuroscience Society.

Hopkins, L.S., Christopher-Hayes, N.J., Helmstetter, F.J., Hannula, D.E. (2016). Contingency awareness is not required for fear conditioned capture of attention. Visual Sciences Society. Public Link

REGIONAL CONFERENCES

Nguyen, B.D., Christopher-Hayes, N.J., Ghetti, S. (2023). Associations between Fitbit Biometrics and rsfMRI Quality: A Cross-sectional Investigation from the ABCD Study. University of California Davis Psychology Spring Conference.

Phipps, C.J., Christopher-Hayes, N.J., Torres-Russotto, D., Warren, D.E. (2019). Measurement of functional brain network connectivity in people with orthostatic tremor using MRI and transcranial magnetic stimulation. University of Nebraska Medical Center Annual Research Day.

Pham, D., Christopher-Hayes, N.J., Rangel, A., Stephen, J.M., Calhoun, V.D., Wang, Y.-P., Wilson, T.W., & Warren, D.E. (2017). Brain correlates of memory ability in youth. University of Nebraska Medical Center Summer Undergraduate Research Symposium.

Sajja, K., Christopher-Hayes, N.J., Warren, D.E., Madhavan, D. (2017). Predicting outcomes after corpus callosotomy using FreeSurfer for processing and analyzing pre-surgical MRI images. University of Nebraska Medical Center Annual Research Day.

Christopher-Hayes, N.J., Hopkins, L.S., Helmstetter, F.J., Hannula, D.E. (2016). Oculomotor capture by aversive stimuli. UW-Milwaukee Undergraduate Research Symposium.

INVITED TALKS

Christopher-Hayes, N.J.. Neurocognitive risk and chronic disease: The case of childhood asthma. (2023). FLUX Society International Conference. Santa Rosa, CA.

Christopher-Hayes, N.J.. Neuroimaging and Neurostimulation in Alzheimer’s. (2017). Fremont Area Alzheimer’s Collaboration. Omaha, NE.

JEDI/COMMUNITY OUTREACH

NeuroCareer Pathways Series, UC Davis Learning-Memory-Plasticity (LaMP) Program 2023 – PRSNT

Science Education Outreach and Engagement Program, UNMC Science Education Partnership Award (SEPA): Health and science education in Native American communities and The National Cancer Institute’s Youth Enjoy Science Research Program (YES) 2018 – 2019

Fremont Area Alzheimer’s Collaboration, Memory Walk 2016 – 2017

Federal TRIO Program, Upward Bound Math-Science 2014 & 2015

New Horizons Un-Limited Inc., Independent Disabilities Advocacy and Rehabilitation Center for Computer Training, Refurbishing, and Workforce Preparation 2012 – 2014

TEACHING EXPERIENCE

Teaching Assistant:

2021 PSY 135, Cognitive Neuroscience (Instructor, Evan Antzoulatos, Ph.D.)

2022 PSY 103, Statistical Analysis of Psychological Data (Instructor, Shelley Blozis, Ph.D.)

2022, 2023 PSY 146, The Development of Memory (Instructor, Simona Ghetti, Ph.D.)

MENTORSHIP EXPERIENCE

Graduate Students

2019 – 2021 Arif, Y., Rempe, M., Springer, S., University of Nebraska Medical Center

Undergraduate Research Assistants

2022 – 2023 Nguyen, B.D., UC Davis Cognitive Science Major. Project: Predicting fMRI data quality with Fitbit biometrics

2017 – 2019 Craft, S., Decesare, T., Rangel, A., Creighton University

High School Research Assistants

2022 – PRSNT Merchant, V.D. Project: Linking Chronic Asthma to Memory Impairments in Children

SYSTEMS AND COMPUTING

Authored Packages:

1) ArtifactScanTool (AST) – A Matlab-based package for automated statistical identification, rejection, and plotting of artifactual MEG channels and epochs. Versions available for BESA and Brainstorm software packages. Download here

2) PyStiMEP – A Python-based package for automated neurostimulation event-related motor evoked potential (MEP) identification, extraction, and plotting

3) Snapshot – A Python-based package for basic financial management and monthly reporting

Software:

FreeSurfer, Brainstorm, FSL, ASHS, AFNI, SPM, Fieldtrip, 3D Slicer

Hardware:

Siemens Prisma/Skyra/Trio 3T MRI System, Elekta MEGIN MEG System,

Eye-Trac 6, Eyelink 1000, Nexstim NBS 5.1

Languages:

Python, R, Git, Bash/Shell, Matlab, Java, HTML

CERTIFICATIONS

2014 – PRSNT TMS (NBS System 5.1), MRI Safety, CITI

HOBBIES

Avid English Premiere League Observer, Photographer sometimes, Guitarist almost, Pianist once upon a time, Soccer when I feel young, Snowmobiling please, Boating with buoyancy, Hiking seems healthy, Programming inseparable, Opensource fanatic

RESEARCH REFERENCES

Dr. Simona Ghetti Professor, Department of Psychology Center for Mind and Brain University of California, Davis One Shields Avenue Davis, CA 95616 sghetti@ucdavis.edu

Dr. Tony W. Wilson Patrick E. Brookhouser Endowed Chair in Cognitive Neuroscience Director, Institute for Human Neuroscience Boys Town National Research Hospital 14090 Mother Teresa Lane Boys Town, NE 68010 tony.wilson@boystown.org

Dr. Kimberley A. McAllister Professor, Departments of Neurology and Neurobiology, Physiology, & Behavior Director, Center for Neuroscience, NIMH LaMP T32 Co-director, UC Davis Conte Center Center for Neuroscience University of California, Davis 1544 Newton Ct, Davis, CA 95618 kmcallister@ucdavis.edu

Dr. Deborah E. Hannula Associate Professor, Associate Chair, Department of Psychology University of Wisconsin-Milwaukee Garland Hall P.O. Box 413 Milwaukee, WI 53201 hannula@uwm.edu

Dr. Alex I. Wiesman National Institutes of Health Postdoctoral Fellow Montreal Neurological Institute McGill University 3801 Rue University | Montréal, QC H3A 2B4 aiwiesman@gmail.com

Dr. Daniel L. Murman, MD, MS, FAAN Professor, Department of Neurological Sciences Director, Behavioral and Geriatric Neurology Program University of Nebraska Medical Center 988440 Nebraska Medical Center Omaha, NE 68198-8440 dlmurman@unmc.edu